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noise in the room

Hello vets,
I live in an old house and I play and record in a room within. I have an audio box usb (presonus) with the studio one v.2. Also, have qsc 1450 and cabs. I can play into the audio box/ Macbook Pro and hear no noise through headphones. I cannot play songs off the internet nor tracks from studio one thru amp into cabs without getting the dreaded 60hz hum. Obviously, the noise is happening after the audio box, and probably after the power amp or in the electric conundrum somewhere :banghead:? Looking for a cheaper alternative to running another line dedicated to just the audio rack, which I assume would solve the problem… the old adage of everything grounded together?
Looking for real world help here,
f n o r d !