As stated there could many causes for this problem. Here's one of the strangest I've run into that had similar symptoms.
This may not be the problem, but....
In some combo type amps this may be caused by the basket of the speaker not being grounded. If the baffle board extends up to within a short distance of the preamp and the wood of the baffle board absorbs moisture becoming semi-conductive, there will be a "feedback" loop established between the output of the power amp and the input of the preamp. If the speaker basket is not grounded, grounding it MAY solve the problem.
The basket would be grounded by running a wire from the (-) terminal to the basket. Most speakers will have a basket that is grounded by the hardware of the speaker terminal.
mech