On my board, I have a Bassbone for bass switching and gain balancing first, then tuner into an HX Stomp which i guess is a MEP though it really seems like more... I have a synth in each of the two Hx EFX loops as for me, that is what the HX can't deliver. As far as comp, light dirt (Timmy/Teemah), modulation, eq and sims go- the HX does fine. I control the synths and the HX via a combination of the HX foot switches and a Morningstar midi controller.
For me... On a blues or country date, I could easily take the HX and a Big Shot i/o alone.
I always cable at least 2 basses so the switching and gain balancing thing for me is huge...
in my case a combination of MEP, special stuff in the EFX loops and pulling it together with a midi controller seems to be the best bet. Particularly
in a live setting. Maybe in a recording setting having 4 boo-teak drives to choose from makes sense but live ? The nuances kinda get rounded off...
I put a several hundred gigs on a Zoom B3. I treated is as 3 effects per bank and used maybe 5 or 6 banks. I was not at all unhappy with that thing. Got many compliments on tone and often got questions about what was that thing you used in that song ? Always a variety of envelope and octave plus direct or flange... I spent time on my patch levels and bass content and... efx are I believe best used sparingly. I might have used a mild comp and light drive for of a blues date- we segue into that funky vamp jam and I'm stomping the synth! but then it's off and the shock value has been applied to the crowd. So... give the rarity with which you apply them spend big on the impact efx and rely on the MEP for core duty. Now, which are the impact EFX ... that is going to vary player to player. In my case a C4 and a Future Impact are just IT. For someone else it might be a super snazzy distortion, modulation, echo or...
My guitarist is experimenting with a Strymon Iridium and a Big Sky. He has several boutique pedals for dirt (original 70's Tube Screamer which truly rocks), delay, chorus, etc... I can see him migrating to an FRFR and leaving the stereo Rivera / Mesa combo's rig home. I could to a Helix LT for more processor power. We could easily be ampless next season...
The current batch of MEP's are ridiculously useful.