What's more comfortable is preferred.
With Fender necks, I don't use pinky over 12th fret - only if it really can't be done otherwise - because it hurts the natural position of wrist. Even in fast tempos I prefer to switch positions, using only 1-2-3 or even just 1-3. 3 is strong enough for all of the bluesy bending and vibrato stuff. @Papageno 's thumb idea is great, I use it too, but I don't recall ever really needing this outside solo playing. It's a great help for playing nice jazzy chords.
On my Pedulla fretless with two octave neck-through I can safely use pinky up to about 18th fret.