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Please help save my back

If you're handy with tools and woodworking go with a fEARful 12/6. Mine is 39 lbs and cost around $450 to build. It also sounds great. I run a Genz-Benz Streamliner through it and that makes a very light and powerful rig.
 
+1 on the Aguilar TH500 for an amp, less than 4 lbs. There are many neo speaker options out there. I have both a Markbass combo that is 350 watts and 45lbs, and I pair my TH500 with a Bergantino CN212 with a total weight of less than 50lbs. Bergantino stuff is pricey however but worth it in my opinion. It's great that there are so many light weight, good sounding options out there now. A good transport cart is a good investment too!!
 
I personally use a 410 with an 8 space rack stacked on top. The only time i lift either is in and out of the car, the rest of the time i roll it around on casters. The wheels on the 410 are small and don't roll really well on asphalt but my driveway is concrete and most of the venues i play have a concrete sidewalk i can roll it on just fine. I've used just about everything from multiple 210 cabs up to an 810. The 410/212 size cab with 4 wheels works best for me. With tilt and roll style cabs like my old ampeg 810e, ampeg 410hlf, and swr610 it varies. Out of the tilt and roll cabs the 810 was actually the easiest to roll, the 410hlf was miserable to roll because it was much shorter. The problem with all those cabs is i had to bring in my rack separately. With 210/112 small cabs my problem was they are to small to roll around by themselves so you need something else to help move them, as shown above. Small cabs are nice if you live on the 3rd floor of an apartment building and have to go up and down stairs, 810s are nice with a band trailor with a fold down door/ramp. But for transporting in a car I'm happy with my rig.

When i get to the venue i set my cab on the ground, stack my rack on it, then put my bass i bring in a gig bag on my back. If i use effects i bring them in a backpack. Its a one trip load in, no deadlifting gear into the venue, no multiple trips to outside.
 
My first really good amp was an Acoustic 400 head and 2 x 15 cabinet that had wheels that you could tilt it back and roll it around. It was still a b*tch to move around, because you still had to left it into any vehicle. Aren't all heads and cabs basically heavy?
 
Fender P bass in a gig bag with shoulder straps goes on my back. Some extra cables, and music sheets are in there, too. Ampeg PF-350 in a laptop bag with cables. A bit over 10 lbs. Pedal bag with... pedals, and more cables and extras. I carry the amp bag and pedal bag in one hand. That's about 30 lbs. A fEARful 12/6/1 cube in the other hand. About 40 lbs... still one hand carry.