Great!
One possibility is that your mixers power amp has a jack, maybe called Power Amp In. These jacks are typically what's called a "switching jack" and here's how they are designed to function: when nothing is plugged into the Power Amp In, the jack has an internal set of contacts that closes a connection between the Preamp Out (or Mixer Out) and the actual circuit that connects to the power amp. So whatever comes out of the Preamp or Mixer gets internally sent to the power amp. When you plug something into that Power Amp In jack, however, the jack opens the internal contacts from the Mixer or Preamp side, and instead accepts whatever signal comes through the plug and sends that signal to the power amp instead.
Often, these internal contacts get a little bit of corrosion just like a pot. The result will be just like opening the jack's internal contacts, meaning the signal from the preamp/mixer side is cut off...but there's no signal from anywhere else going to the power amp. Dead silence, or sometimes a muffled signal. Deoxit can fix this too, but sometimes it takes working the jack several times to help clean the contacts.