You have to evaluate a couple of things first:
1) If they have different impedances, the one with the highest impedance will receive more power than the one with the least (as opossite to parallel wiring, where the one with the least impedance receives more power) and this is not always desirable (sometimes it is; I use a Hartke 4.5XL -8ohms- and 215XL -4ohms- hooked in parallel to the same amp and they sounded nice with the 215 receiving double the power than the 4.5, but results may vary).
2) If their impedance curves are too different, you may end up having impedance peaks at way different frequencies and this causes almost all power to go into the speaker that's having the impedance peak and almost nothing to the other (this happens only at certain frequencies but if it does, it's noticieable, believe me).
Good luck!
ANDRUCA