No, it should sound exactly the same.
Personally I wouldn't find much of a need for the programmable version; I just don't find it that versatile. I really do like the BDDI sound but if I have a three-channel preamp I want to be able to dial in more radical differences.
However, the programmable is only 10 bucks more. Unless you're concerned it would be physically too big, go for it. I can't justify upgrading from my original version, but I'd go with a programmable if I didn't have the original already.