Hmm... You've all given me a lot to think about.
How does a 410 fair with comb filtering? It is essentially 2 sets of side by sides but all in one box. Or is comb filtering a significant issue with 410's?
I'm just playing advocate trying to get as much info on the subject as possible!
Is comb filtering a major issue with bass vs guitar cabs?
Cause you'll likely have a hard time finding a vertical guitar cab but rarely hear of any issues with them and comb filtering.
Remember, beaming and comb filtering become gradually more of an issue as you get into the higher frequencies (1K and above). If you have a 410 with a tweeter, which is typically crossed over around 3K, you have a relatively narrow band of upper midrange that doesn't spread quite as well compared to an individual driver or vertically aligned driver stack, or a smaller midrange driver that is crossed over around that 'problem area' (i.e., 1K or so). The 'spread of bass' around the room is not impacted at all.
With guitar, it is much more of an issue, since the vast majority of a guitar frequency response is in that beaming range of frequencies, and since the vast majority of guitarists don't use tweeters, the problem extends all the way up.
There is always a trade-off is these cabinet designs. For me, given that the 410's I've used through the years had tweeters, and since my tone tended to minimize what I call the 'gank area' of the upper mids (that harsh 1K to 2K area), the issue of off axis response performance reduction with this style of cabinet was pretty minimal. Also, many mid drivers that I've experienced have a tonality that I don't particularly care for, so always trade-offs with any design decision.
That being said, if you are using a 212, it is a no brainer to set it as 'vertical' as you can... nothing lost, and 'horizontal' 212's beam a bit more than 10's (due to the wider diameter of the combined speakers).