As a point of reference, I have arthritis in the knuckles of both hands, but on the fretting hand, it cause issues on some strings... case in point, Chromes, which is what came on the bass when I bought it.
While I prefer the sounds of flats, the Chromes are much too stiff for my knuckles. Next came D'Addario tapewounds, also stiff, but not nearly as bad as the chromes. Also didn't really like the sound of those, cause they were just a bit raspy?? Next came some used D'addario 1/2 rounds, and while I liked the feel of them, and the sound for the most part, the E was dead but the rest weren't. Gig coming up and had to change them so I went with D'addario XL's. But I'd really rather have a flatwound sound if I could.