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String Gauge/ EB Cobalt Question

So - for a very long time now I've been using nickel wound strings with a 45,65,80,105 string gauge on my MIA Fender Jazz. Works for me and I get the tone and feel that I want out of the bass. This gauge of strings has always been my go to size and I don't have a lot of experience using other gauges because I'm a creature of habit.

But I've been reading about these EB cobalt strings and am thinking about trying them. Unfortunately they don't have my usual gauge. They come 45-100 or 50-105. So my question is this: is there really that big of a difference between the 45,65,80,105 string gauge and the 50,70,85,105 to make it not worth my time to try these cobalt strings? Or is there really not that much difference between these gauges to really worry about it. Just asking for your personal opinions. I know that I'll have to do a complete set-up on my bass if I go with the heavier gauge cobalts - but I'm good at setting up/adjusting basses.
 
That's not that big of a difference. As long as the nut is cut well they should sit in there good. I'm a flatwound guy and dig how these feel and sound. Not sandpaper/rasp feeling but not smooth...to my fingers they are easy to pluck and fret. I have the extra slinky 45-90's on a Jag and the 45-100's on my Nash P. They tune well and sound pretty cool.
 
Cobalts are available in a few different gauges...

Extra Slinky: .040 .060 .070 .095
Super Slinky: .045 .065 .080 .100
Hybrid Slinky: .045 .065 .085 .105
Regular Slinky: .050 .070 .085 .105
Power Slinky: .055 .075 .090 .110

So you can get the Hybrid Slinky set .045 .065 .085 .105 which is as close as it gets to your ".045 .065 .080 .105" set.