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String gauge question

Just added some drop D songs to our set list and I am interested in opinions on string gauge. I've always used .45-.100 and love them but would it be better to go with a .105 set? I suppose I need to just try it and see what I like. Anyone else useing .100 for drop D?
 
My E-string is a .090 which is the equivalent of a .100 tuned to D.
I find the problem to be is the difference in tension from one string to the next when you take the loosest string and tune it down a step. I down tune my 2 lowest string often, so when choosing strings I make my set out of single, so my lowest strings are the tightest.