Electrical interference shouldn't be a big problem, even with unbalanced cables, because hopefully your cables are short, shielded and because the signal from the interface to the monitors is low impedance.
Does the crackling only occur when during playback? If so, then it could be a latency (data delay) problem with your interface. Are you new to computer recording? You may have to change the "driver model" your interface uses, for recording purposes using an ASIO driver is preferred, but often an interface will default to "WDM" or something because, you know, Windows® knows what's best for you! (usually). This means tweaking the drivers and settings for your interface, and that's usually done through your recording program. (also called a "DAW" for "Digital Audio Workstation")
In general computer recording is great, but these kinds of problems DO pop up and cause headaches. One company makes your interface, another company makes the DAW software, yet another company makes the PC hardware and still another company (most likely Microsoft) makes the operating system software.