Was talking about playing the doghouse at a party a while back and there happened to be a dermatologist who was listening. I asked him what's the proper way to care for a blister since he's a pro. Bottom line: Do not pop it! The blister is filled with a serum that the body naturally creates which speeds up healing. The fluid will get reabsorbed as part of the healing process. Got two blisters last night due to someone elses bass and lack of practice lately. Already a day later and it's almost flat again.