Are you using any effects ? If so you may need to compensate there. I bought a new GK rig 1001RB,NEO410, and NEO115 and couldn't wait to get home and plug it in. I immediately noticed noise with the treble. I thought the horns were blown or something. After playing with it several different ways, I noticed the noise went away when I turned the treble down. This was puzzling because I had been running through a GK 210 combo with great results. I run through a DigitechBP200 for effects. When I took that out of the loop, the noise went away. Just had to reprogram some channels. Something about the "Boost" control on the head and the effects were not cooperating.