If you like the amp portion of any given combo (and if it's reasonably powerful) you can always add extension cabs. Having the option to have a single-hand carry might be more important to you than the added flexibility of a separate head and cab. My 2¢:
I've been carting around a 210 and an amp in a rackmount case for a more than a decade. It was tolerable for a large portion of that, but in the last few years I've also built out a pedalboard. That was one more thing than I had hands (and back) to carry in a single trip, which started to get annoying. Also, setting up and tearing down the piecemeal kit at every rehearsal was a chore when I was using it 5+ nights a week - you have to take the front and back off the rack (or take the amp out of the softcase), grab your speaker cable, etc. And during periods when I was gigging heavily, I'd rarely want to get home after a gig and set up the rig at home only to tear it down the next day. This discouraged me from practicing, an unexpected knock-on effect.
I got a combo a few months ago and love it. It's great to keep the power cable in my bass case and just grab one item on the way out the door. If I had to have only one amp, I think I'd go with a decently-sized combo. I got a 115 (Rumble 200).
Also, there's no reason you can't eventually have both if you wish. I went from a midsize rig of separate amp and cab to a combo, and soon I'll also have a "big rig" 215 as well to go with my standalone amp. The idea is that the big rig will mostly stay at home, always set up for practice, and the combo will stay packed and ready to walk out the door.