Well, I think there are two good concepts to keep in mind - boiling the frog, and dropping the bass...bear with me.
By boiling the frog, you play most of the song or section in a higher register so people get used to that as the proper level of low end but you've kept your gravy notes in the bag for the big finish or kick in after a build - gives this sudden sense of huge width of frequency range in the big parts.
Dropping the bass is very similar but more keeping the low notes as sparsely used as possible, using them to emphasise or as the release after building tension by playing higher in the range.
Some songs I will start up very high, start dropping lower notes in, them switch to the mid register, then finish the song playing the lowest notes I've got.
It's mainly realising that higher up fretboard = building tension, lower down is release.
I tend to play more notes when higher up, but stick to my knitting down the low range.