Again, I went back and listened to the song again because I figured there must be something I'm missing. I guess I'm missing the difficulty in playing this line on a 5 without detuning
Is this the song? Yes it's easier with an open Eb but it's far from difficult IMO on any of my fives. And if it doesn't sound good on a particlular five, all fives aren't created equal. And I use a .120 or .125 B because it's closer tonally to my E strings. I can play this line on the low B string alone OR a combination of the Eb on the low B (and let that note continue) and the rest on the E. So I can switch it up vs. having only one position that I have to play it in. It can be
less repetitive on a five.
I don't have anything approaching carpel tunnel, that can be a product of technique just as easily as ergonomics.
BTW if anyone chooses to read any of this as "berating", there's nothing I can do about that. That's on you.