Thank you for these answers, I've been curious for a while.
The scenario I had in mind is, in a pinch, running a "standard" dynamic mic like a Shure 58 through my combo bass amp primarily for voice, possibly with acoustic guitar, and/or banjo, with an acoustic DB in the background -- not expecting it to pick up much but the voices.
This is not something I'd expect to replace a good FOH with, but something I've kept in mind as a possibility since a festival we played at where the FOH sound crew had a schedule screw-up and missed our Sunday Gospel Hour show by 30 minutes...
We ended up moving off-stage and played completely without mics under a tree for an hour to between 100 and 200 people in the audience who were basically standing up in front of us. While it was a great experience for us and the audience, and really something that acoustic artists often dream about doing, our vocalists had sore throats for the next couple of days from having to push the volume so hard. A single mic primarily for them would have been nice and probably would have saved them from having to push singing so loud.
Obviously the sound crew were a little embarrassed but the show had to go on.