Hi
It depends what you want out of your rig, I replaced the 15" Goodmans (when it blew) in my Trace Elliot combo with a Eminance. It did not have as much top end and all sounded a bit dull. I added 2 cheap piezo horns (no crosover, just a couple of resistors so I don't fry them) and it sounds better than it did before. If you are after lots of midrange and hifi quality sound then go for crossovers, bass, midrange and a compression driver horn, but for a usable rig to gig with you can forget about the subtleties and whack in however many piezo horns you need to handle the power. On my rehearsal rig I have 2 horns and a volume pot as there was just a bit too much to end.
I think Bill's suggestion of 4 peizos is a bit OTT for a 2X12 cab. In my experience with them I have used a Peavey 4X10 with 2 in, that was more than adequate, in fact I had to put a pot in to shut them up a bit. I have a home built 1X12, with one in that needed a volume control. My giging combo has 2 in for a 280W output, with no pot, the less controls you have to play with on stage the better.
I play in a trio playing small venues, so tend to play with quite a lot of deep bass, not a lot of mid (as the guitarist fills that slot more than adequately) and just enough top to to cut through without sounding like breaking glass. I play either an MM SR5 (coils in series), MM SUB4 (coils in parallel), that can get too toppy very easily, or on rare occasions a 62 P bass which is not as critical on amp settings as the 2 MMs.