When you set gains you solo/PFL each mic/channel and set gain level so Main meter is around 0, not Peak.
I'm sure this varies manual-by-manual but the Soundcraft recommends hitting the amber section with only occasional peaks to the red LED on the loudest passages. Either way, you want to saturate the channel for the best signal / noise ratio. Pre-gig adjustment is close at best as levels tend to rise during a live performance thanks to adrenalin-driven vocals and stage / backline volume bleeding into the vocal mics.
Riis