If anything I think the fretboard layout is more logical and straight forward on a 5 string, because you got 3 octaves mirroring each other across at any point of the board, so it is easier to orientate one self on the fretboard to start with, locating notes, doing scales, chords e.t.c.
However if you got small hands a 5 string might propose a greater physical challenge to start with than a 4 string would, the fretboard being wider.
I do not have the longest fingers, and I literally can't fret the lowest string above about the 12th fret with my pinky, unless I swap my thumb up front (instead of holding it in support behind the neck), even if the string spacing is about as tight as it gets, just 16.5mm.
String spacing is definitely a thing to consider, if you decide in favor of a 5 string, as it determines how wide the fretboard gets towards the end of the neck, but also, obviously, how much space you got to pick the strings in between.
Personally I like the tight 16.5mm string spacing, but I know that not everyone appreciates this, and prefers 19mm string spacing, even if it means a wider fretboard.
Another thing to consider is the tuning, some people prefer to tune it E to C, getting extended upper end (fairly common for jazz), for chord and melodic work, rather than the extended low end, the traditional B to G standard tuning of a 5 string.