I'm going about 50/50 hardware/software and should be done with my setup in the next 2 weeks or so. I'm using an Axe-Fx ultra for all of my amp modeling, time-based, and modulation needs. My Nord G2 Engine handles most of the synth and external filtering. I'm using my Macbook (non-pro) right now but I have a Mac Mini on the way that I'll be mounting in the rack. It's going to run Ableton 8. Then I'll have a MOTU Ultralite Mk3 that will be used as a firewire interface and mixer w/ effects. Since all of the mixing, synthesis, and amp modeling won't require any of the Mac's processing power, it'll be free to run pretty sizable VST's. I'm going to be running the StringPort for my pitch->MIDI needs. It converts pitch->USB 2.0 which I'll then convert to MIDI. That will definitely be loads faster than pitch->MIDI could possibly be and get my latency down to about 5ms, maybe even less.