I played nothing but 5s for the entire 2000's and flat out could not play a 4-string during that period. But around 2011 I decided I wanted to "start over" with the instrument so I got a 4 and forced myself to relearn that instrument. I got completely comfortable on that, then added a 5'er strung E-C to mess with chords and different ranges, and now have swung back to mostly playing 5-string B-G. I still pick up my 4-string but my "comfort" has migrated back to 5. That said, if I play 4 regularly then I don't have problems switching. If I don't play the 4, then I do have problems. So it really is just time/effort spent woodshedding. 4-string and 5-string are different instruments...
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