I used to create all the backing tracks for my old covers band and duo. I started out my sourcing the best midi file of the song I could, edit it if necessary in Cakewalk Sonar so that parts were in the right places, add in click intro's and proper ending if originally faded out.
Then I would plough thru my samples and virtual instruments substituting the midi sounds with real instruments, althought I tended to go for the same few to keep things consistent. In particular I always used the same drum kit samples. Although you may think it great being able to use different tailored instruments for every song, in reality, it's a pain to play along to live, as it doesn't sound right anyway if the drums tones keep changing and it screws up the mix of the live instruments.
You may want to check out Propellerheads Reason software if you're only planning on using midi. This has some of the best samples and virtual instruments I've heard in a box set. It does require a bit more learning than your average sequencer to get going, but once you've cracked the logic behind it, it's wonderful. It can be hooked up to other sequencers too as a sound source which makes it really versatile.
I'd also make sure the volume of the drums was the same on all my backing tracks to keep things consistent and to increase the likely hood of my finished mixes being more or less the same in volume. You may need to check the velocity here too as well as the volume.
Even though I would be taking the bass, guitars and vocals out of the final mix, I'd leave them in there as guides whilst mixing so I could get the other parts to sit well.
Once I was happy with the mix, I'd perform some basic mastering. A tip here is to load all your backing tracks into a new sequencer file in separate tracks, then load an eq and a brickwall limiter/loudness maximiser into each track. Eq out everything below (I think) 80hz, which stops the sub bass rumble you make get when played back in the PA, then use the loudness maximiser to get the best volume out of the tracks and match them for volume.
Before I used to do this last step I had such a job getting a decent volume out of our little fender passport 250w PA. Mastering transformed them. We were able to comfortably fill a large hall at functions with such a small and low powered system.
This may be way to much info for you, but if any of it helps, then I'm glad I could help.