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Just in terms of "is it an equally good idea", yes--absolutely. No problem, good approach.
If you really mean "equal in all specifications", literally, then no. Different box sizes and tunings produce different specs. Plus it depends on which specific 210 and 410, since they all have slightly different parameters.
. My current gig rig is a 210 combo. I've ordered the matching 210 extension cab and once it comes in I will be finding out whether or not this is true. By having all the drivers vertically aligned I'll be able to hear myself better, as the topmost driver will be closer to my head then it would in a 410 configuration. As for resolving phasing issues, I will hook up my trusty wireless and walk the room and see.My belief, & I know that of many others, too, is that the often mentioned 2 x 210 setup, stacked on their sides for a "vertical" 410, is a far superior format to that of the square 410.
My belief, & I know that of many others, too, is that the often mentioned 2 x 210 setup, stacked on their sides for a "vertical" 410, is a far superior format to that of the square 410.
A very emphatic +1, for all the obvious reasons: modularity, drivers closer to ear level, better dispersion, yadda, yadda, yadda ad nauseum.
Truth be told, I started vertically stacking my 2x10s when I bought my GB STM900, just because I thought the smaller head would look cooler on top of a taller, narrower stack. Purely an aesthetic decision. Cheesy logic? Yes. Little did I know at the time that all of the benefits listed above would conspire to make me a much happier bassist.
OP, if you're looking into 2x10s because of back problems, you might consider a single FEARLESS F210. They're purported to "go as loud as a good 4x10" (so you'd theoretically only need one), can handle a ton of wattage, and are very light.
Number and size of speakers is no way to assess a speaker cabinets properties.

And strange women lying in ponds distributing swords is no basis for a system of government, either!
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Within the same make and model, the 2x10 often has a slight edge in net cabinet volume compared to half a 4x10.Are two, 2x10 cabinets equal to one 4x10 cabinet in all specifications? I have a funky back and want to male loading lighter.