I'd start with the bass at noon, only boosting it a bit if needed. The low-mid is where your punchiness should be found. Boosting here might make the bass seem louder too as they're frequencies you can hear rather then feel. High-mid is where you'll get your cutting frequencies. So if you want to make your sound more up-front and add an agressive character this is where boosting it is good. Similarly if you want to dull your sound you can cut these frequencies.
Lastly you have treble at noon which is where I leave mine. Typically this is where you find string noise so I don't like to boost it but cutting it means effects, distortion, nuances, and perhaps even your sound all-together can disappear in the mix very easily.
I don't have specific experience with the old V1 100, only the 75. I find them to be dry amps as it is and 15's tend to add dryness to the sound as well. (Though this isn't always the case.) So to a degree you'll have a less exciting sound, for lack of a better word. That's not a bad thing, I find every speaker size brings something to the table it's just something to keep in mind.
Oh! Also just start with the amp at noon and just go from there. Your ears will tell you when they find a tone you like. Then just keep in mind with a band you likely need a lot of extra mids to go with that but on your own you can do whatever. And the mid-scoop switch is for slap, basically. You could use it for anything else but it essentially takes all the fun frequencies away. It works for slap because it's such an aggressive technique and it enhances that, but everything else needs those frequencies.
Embrace the mids! It's a whole different bass world when you bring them forward a bit.
And worst case scenario you could pick up a cheap 10-band EQ pedal and run it right before the amp or in the effects loop (if that amp has one). Theoretically you can make any decent amp make any sound you like so long as you work the proper frequencies, technique, and gear into the equation. So the sound that is bass guitar to you is probably in there somewhere.