That's alot of cabbage
How on Earth does a Mesa 400 even run that many cabinets
It will run all four Hartke's with aplomb using a series box I created to match the impedance to an acceptable level that the 400 supports. The Mesa replaced an Ampeg SVT6Pro that bit the dust due to bad generator power one day at a live event. The Mesa/Ampeg fridge rig was mine until my church bought it from me (to replace the Ampeg) so I combined them all together. What you don't see is a power amp that took over powering the Hartke cabs, and I ran a power cable down to the Ampeg fridge on the bottom. It's a glorious pants-flapper for sure!
For our next show I just have the top two 410's wired to the Mesa - it reduces our stage volume, allows me to hear myself clearly (even with earplugs - that are always worn) and since our stage is elevated, it keeps the sound over the crowd so the FOH can do more work (i.e. more control over house sound/volume). The guitarist's full stacks are just running the top cabs for the same reason; our show this Saturday will be the first time we've played like this and so far, so good.
I'm more than eager to find out how these act in a live setting with an open room. More than likely, not very well, but I'm sure they'll work for what I need.
Sorry to hijack your thread, OP. I too have wanted to assemble a vert-410 rig until I got my Bassman 400 combo - it's all I need for anything less than the Mesa/Fridge combo (and it belongs solely to me).
However, some time ago I played a janky rig that I assembled from a Sonic 210 cab (sealed), a Hartke 1400 amp, and a Hartke 12" Kickback, all stacked vertically. This was done in a much smaller room (1800'?) and wound up using this for to different shows.
It really worked quite well - in one room I had the stack pushed back into a corner and it was incredibly boomy - I pulled it out about two feet and that was a great improvement as it sounded good on stage and in the room (had some help from a small PA). I agree with other's statements that you do what sounds best in the room, whether flat on the ground or stacked.
But I'm 6'5" tall, and that's why I sold my Mesa M6 Carbine combo - it fired too much sound at my knees, so I don't know how you can hear your rig if it's flat on the floor.

Let us know how it goes for you.
Raz