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how many in the chain is safe?

Well, there's no 'rules' per se, but bear in mind, the more pedals you run, the more prone your signal is to noise and tone/volume loss. A good pro multi-effect unit will let you lay on the sonic sauce pretty thick without this problem, but ANY effect using a higher gain structure will produce some noise.
 
Well, there's no 'rules' per se, but bear in mind, the more pedals you run, the more prone your signal is to noise and tone/volume loss. A good pro multi-effect unit will let you lay on the sonic sauce pretty thick without this problem, but ANY effect using a higher gain structure will produce some noise.

Using power supplies with isolated outputs and quality cables will help with noise as well.