Did you regret? Which pedals you replaced by the multi effects?
Did you stay only with the multi effects or you board has a mix of it (pedals + multi effects)? Which pedals you couldn't "let it go" in your board?
The TL;DR
What it comes down to is A) personal preference and B) what works best for YOU. The best suggestion is to try one out for yourself.
I went full circle: multi-fx > single pedals > explored Multi units again > now my main board is a mix. But I've also been quite happy gigging just the Stomp (when I don't need synth... keep reading below).
The more wordy answer 
Like many players just starting out, I started with multi-fx units: a Zoom 506 Bass, Korg AX1B, and a Digitech BP-8 (which I still have) and then switched over to single effects because that was "what I was supposed to be using." I went down the rabbit hole and explored a LOT of pedals for quite a few years, including a lot of boutique stuff. Coming full circle, I picked up a Zoom B3 as an impulse birthday present for a cruise ship travel gig with a gospel band, and that sent me exploring the current state of multi units again. I bit the bullet and tried an HX Effects after much research, and quickly bought a Stomp shortly after.
There's always going to be the idea of "single pedals sound better," and there's nothing wrong with that. In some cases it's true, but I would argue that that's not always necessarily the case. The Line 6 team puts a LOT of effort into their models and it shows. I've seen a few comparison videos on Youtube that are quite favorable to the actual counterparts. Being a previous single pedals guy myself, I know that sometimes that mentality can color one's opinion. (I was a single pedal snob for a good many years.

) In my previously mentioned pedal explorations, I owned or tried 38+ individual envelope filters, and the Auto Filter in the Stomp is among my top 3 favs. (3Leaf Proton V2 and Pigtronix Bass Envelope Phaser are the other two for some context).
Some multis have a pretty complicated menu diving system, but I found the Helixes to be pretty intuitive, with just a little bit of time to get up to speed on how everything operates. It only took a day or two to get used to it, and making adjustments became quite easy... It's not actually that far from adjusting single pedals.
The Helix family (and the PodGo) all share the same effects models, and there are many VERY good sounding models. Several have become my favs, and what you can do with combinations is endless. Switching to a Stomp was a "quality of life" upgrade for me in my current gigs. IMO, the only true weak point of the Helix line is synth, so I've got the C4 and Future Impact on there, along with a couple other pedals for fun/because I have the space. I've gigged just the Stomp itself on many occasions, and if I didn't need the synth for the 80's stuff, my ideal small board would be a Stomp with the MC6 and an expression pedal. You don't even need a DI because you can switch the outs to line level.
My board is set up with MIDI, so it's super easy to completely change my entire board up on the fly. In particular, I sit in with an 80's band that has an entire MIDI setup for everything (even including lights and backing tracks), and I wouldn't be able to switch effects fast enough for how fast they transition to the next song. I get a MIDI send from their system that changes my pedalboard for me including in the middle of songs in a couple cases, and I don't have to touch my pedalboard all night except to tune.
Here's my current board. The Stomp and MC6 combination do a lot of the heavy lifing. Empress is at the beginning of the chain to balance levels between basses, smooth out signal for better synth triggering, and a hint of preamp colour as well. (I also run a compression block at the beginning of the signal chain in the Stomp, which works perfectly when I'm running JUST the Stomp.) Dunlop Mini Vol X is used as an expression pedal, routed through the MC6 so I can use it to control the FI, C4 and HX (or combinations of all three!). JC Wah is just plain badass.
Bass > Empress > FI > C4 > JC Wah > Stomp > out to house.
A lot of people use a Helix of some sort, and for good reason. Even some of my friends who have been die hard single pedal users have changed their minds after seeing what my board can do (and how easily). One even bought my HX Effects from me.
5sg.