The line out is only coming from the preamp section, not the power section. It would work, but you wouldn't be getting whatever contribution the power section makes to the sound. You'd essentially have a tube pre / ss power, like many of the hybrid amps on the market.
To get the power section of the tube amp working, you need to connect it to a load, either a real speaker or a speaker siumlator / dummy load.
So if the question is "how do I get the sound of a 100 watt all tube amp, only louder" I'd say the options are:
1. Mic the cab into the PA, as someone suggested
2. Use two or more 100 watt all tube amps
3. Use a dummy load and run the output to an SS power amp
4. Use a modeling amp or software
True tube aficionados will say that option 4 isn't the same sound, but as far as I'm concerned it's close enough for live performace and it's a lot simpler.
My $.02