Biamp mode gives you level control over the highs and lows, whatever the 4x10 can dish out before farting the 15 will fill in the mids and highs. Tweak the crossover frequency for best result, somewhere between 200 and 500hz I expect you will find a sweetspot where the crossover and cab phases sum well.
Interesting you noticed it sounding hokey with the last test. Did you try to eq down the higher frequencies duplicated by the 15 to at least get some balance? If you did and it was still hokey that would tell me those cabs weren't meant for running together full range ever.
Separating frequencies for applying effects is a whole 'nuther ballgame. Some biamping amps have separate effect loops, but they are vulnerable to phase twisting causing a cancellation in the summed sounds. Yours might be in that boat?
My effects are run high and low with phase adjustment for my phase inverting fuzz. Putting overdrive and fuzz on highs while leaving lows clean is badarse.
Then there is Billy. There is a world of difficulty in getting dual amp rig sound out through a PA. When you're Billy you probably have a dedicated soundman just for your rig. Doing it with effects and a mono amp is very much easier. I digress.
Bring on the biamp test!