One specific clarification: In Alembic Series 1 / Series 2 instruments, i.e. the ones with true single-coil pickup + a separate dummy humcanceller pickup, all 3 of the "pickups" immediately hit a high-input impedance opamp buffer before they interact with each other.
Feel free to correct me if this not the case, but I
believe that if you're building a system with buffers like this, then the dummy pickup shouldn't affect the resistance/inductance of the single-coil pickups.
This is pretty above-and-beyond compared to almost all other basses out there, though, so for any basses that use dummy humcanceller pickups
without these internal buffers, yes the resistance/inductance would be affected.
As to whether the buffers perfectly preserve the "plain single coil" sound - I'm sure Alembic would say yes

, but my best guess is that the answer is "There is a slight impact, but it's closer to true single-coil tone than without buffers."