Ditto to the DR DDT's. I have an Epiphone Thunderbird Pro IV that I have tuned to C standard. The nut is brass, so filing is a huge PITA. I struggled with various D'Addario and Rotosound strings at that tuning, but when I threw the DDT's on, it felt much better. They're a bit stiffer, and seem to hold their tuning better. They sound great too, not at all flabby. I'm using the 45-105's, but if you have a plastic nut, you might be able to squeeze the 50-110's in (though there's always the risk of cracking your nut). Either way, you can totally tune to drop C with them, no issues. You may even discover you like the options that the looser strings give you. As @Icemanaroonie points out, getting some fret clank in there can really help an aggressive tone.
As for setup, yes, you'll probably need to change things up. The truss rod will probably need to be loosened a bit to account for the lower tension, and you may want to raise your action some to allow for the bigger string excursion. Nothing more than a few minutes work, though...
As for setup, yes, you'll probably need to change things up. The truss rod will probably need to be loosened a bit to account for the lower tension, and you may want to raise your action some to allow for the bigger string excursion. Nothing more than a few minutes work, though...