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Take your 400+ and your bass to the local music store that carries Ampeg, and try them side by side with the same or very simiular cab your using, and then decide for yourself.
I recently sold my 400+ and bought two 4 PROs (one for backup). The Mesa has that unmistakable tube growl, but I never felt like it had much headroom for the low end especially on my 5th string. I could make the head distort beyond what it could do a little too often. The 4 PRO has that thick/round Ampeg tone that finger style playing really excels at. It also has a good growl with a pick and a good bass. I don't miss the tube growl with the 4 PRO. I also have way more headroom for my tone overall with the 4 PRO, I am not going back to tube power sections any time soon because of that.
I will step in here to disagree. I'm not particularly a fan of the 400+, I've always been an ampeg king of guy, but IMO, the 4 pro is NOT ampeg tone. I've been using one for the past month with a cover band I was filling in for (belonged to their regular bass player), and I did not like the tone. I play passive basses finger style, and in this setting I used my 78 fretless p, 78 jazz, and a DJ5, and my V4/8x10 set up absolutely killed the 4-pro/8x10 set up this guy had. If you like tube tone, the 4-pro is not the way to go IMO.