The WA does 500W @ 2 ohms?
yes, it will do 2ohms all night long without any basic issues.
OTOH, my 6 years of experience with my WA at 2ohms (4ohm WA 12 + 4ohm Scout 12) says that the WA gets a little squishy if pushed at 2ohms.
I want the great WA tone, but the clean, warm tube compression version of the WA, not the grindier - gain past 1 o'clock version, so with my basses I run the gain just below noon, and master to taste for the specific gig.
If I do this with the 2 cab setup (so 2 ohms) it seems like it gets too flabby when the master needs to be at noon or more, so I tend to run the gain a bit lower to adjust for that percieved flabbyness effect. Then the master goes up a bit, but as has been reported here more than once, the WA master really does not deliver much more juice after noon-ish on the taper.
A big part of this issue is probable in the passive radiator 12" cabs themselves. I don't think they can really handle much more than 160w or so (each). Another (admittedly all Mesa) approach would be to use WA/Scout 15 cabs, which handle more power.
I really love the WA tone at lower and medium volumes, but like some others here, I am struggling to strike a balance with this amps usable volume and the best ohm level and number of drivers when I need more.
best of luck