I have several gigs with the EBS Sheehan pedal-centered pedalboard under my belt, and I am happy to report that it serves my needs very well.
I cut high mids and highs on the clean channel with LPF (both the EBS octabass and the Broughton RFE are inserted in the clean FX loop).
That way, I have clean lows and driven mids and highs in my signal. I am using the comp switch in the Mid position to glue the two signals together.
I switch between two levels of overdrive with the Boost footswitch.
One specific application is worth mentioning: in a power trio, when the guitarist takes solo, I switch on the octaver and the Boost and play one octave higher. It works great. That way, I substitute for the missing rhythm guitar with the drive channel (the notes I play are within the guitar range) while there is still clean bass one octave lower. It sound amazing!
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