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pickups gone mad?

I was jamming with my band yesterday and my E string broke so I changed only the E string so i could keep playing but for some reason something went wrong. Whenever i play that E string the sound that comes out of the amp is about 1/2 weaker. It never happened in the past so i'm totaly confused. For info i'm tunned in dropped C and use an ESP B-404 SM. Is it my pickup who's got a problem, is it the string it self or the tension in the neck. the strings brand is very cheap could that be it? help please!!