Andrew-
You have a couple of factors here at work: 1. Phasing, and 2. Resistance. As many of the replies have noted, you HAVE to worry about Resistance, and SHOULD worry about phasing. There are a slew of threads on TB about resistance, and is it really that big of an issue. Assuming you are in the know on that subject, here's my 2c.
I would wonder why you would want to do a 4X10/1X15 with another 2X10. That's a lot of stuff to lug around! If it's volume you are after, I suggest a different route. I can't imagine a MESA 1200W Cab not being enough for any setting with an Amp having the proper output. I assume that the cab is 8 Ohm, and that might be a factor, but if you have the 2x10 in there I would think the resistance being divided in half would not counter the overdrive of the 210 due to the wattage threshold difference between the two.
I keep up with some serious volume with a 300W Solid state amp with 2 cabs, a 4X10 and a 4X8 - And I DO have phasing issues. Mix any two cabs/Drivers/speakers of different circumference and you have phasing. Degree's vary, based on delta (Mix a 4X6 with a 1X18, and you will hear it clearly). - Just throw two differently sized stones in the water and you can visualize what this is - Large Circumference speakers are slower, and have less brightness and definition. - Mix it with a small cab of the opposite properties and you get two distinct outputs of sound, or phasing or the sound waves.
The salesperson at GC seemed to be using a subject he knew a little about and applying it for a sale. I have heard those powerhouse cabs, the ones that have the 10/15 in the same cab, and you still have phasing. The question is, does it effect your style of playing?
If so, I recommend one of the following: For Volume issues, investigate your amp. For worry about phasing issues, try a 4 Ohm 6x10, 8x10, or 2x15 depending on your tonal taste.