A note back to the OP. I have only played flats for the last several years. Last night I threw on GHS pressurewounds (like you I crave a more modern bright tone sometimes, in addition the flats felt too grippy depending on heat and humidity. If I was smart I would have only played them for 20 minutes not to risk irritating my finger tips. However, I ended up playing them for well over an hour and I have to report they were very easy on the finger tips (granted I was not doing any trills or real aggressive slides but still). I can see that after just a few more practices with them I won't have to worry about cuts on finger tips like with alot of other rounds.
For some reason the GHS pressurewounds did not have the fret buzz that would be expected with rounds (I had the action fairly low, but not crazy crazy low). I am pretty happy with these strings so I would recommend give them a try but the first time you play them play for only 20 minutes and go easy and then after that spray them down with finger ease spray. Then the next day play them again for maybe 30 minutes (no crazy slides yet though). I bet doing this for just a few days you can play them almost 100% as you would with flats.