The closest anyone has come to changing the effect of a given sized enclosure is using helium gas instead of air in the cabinet. Helium is monoatomic (Helium atoms that aren't bonded to any other atoms), while air is primarily diatomic (2 atoms per molecule) nitrogen molecules. The "spring constant" of a box filled with helium is different than one filled with nitrogen (air), which gives you a small benefit. However, porting the box (and using a driver tuned for that purpose) gives a bigger benefit than helium does in an enclosed box - a ported box filled with helium isn't filled with helium for very long; even a closed box leaks helium pretty quickly, unless it's made from very specialized materials.
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