First time I ever had a go at a short scale, after playing long scale basses for years, I immediately said - that ain't happening again. Felt really weird.
Then I got obsessed with buying basses and started playing anything and everything I could get my hands on. After getting used to many neck profiles I decided to have a go with a short scale again, and it meant nothing to me. I adjusted within a few minutes, and now it really isn't a big deal at all. The one change that I admit was necessary was that I had to learn to play with a lighter touch, but that was something I needed to do anyhow. My band tunes down a half step, and we have a handful of songs we play in drop D tuning. Ya can't dig into an open C# on a short scale without running into problems, but you CAN get it to sound completely awesome once ya learn to lay back a bit.
All I play now are short scale basses. I love them.