[Boring anecdote]
I decided to compose and record some songs basically only using a Bass + Audio Interface + iPad (so amp emulators). I'll take a bit too long with futzing around with the best emulated settings and whatever knobs I haven't turned on the bass. Then start recording...
What I'll realize is sometimes I'll play too close to the bridge (too bright), too close to the neck (too dark), I'll pull the strings too much (too bwahhhhng), not enough pluck (too dinnnng), sometimes I'll get the "I didn't cut my fingernails Geddy Lee sound." The settings are consistent, however my tone is all over the place. My fingers are inconsistent. I did solve the fingernail problem though.
Same goes with using a pick. I can make it even more inconsistent if I switched different pick-thickness and pick-... ingredient (I blanked out on the word).
The good news is that I'm not going for anything professional, so I'll mix all of that inconsistently into an audio mess once every other instrument is recorded... inconsistently. Besides the robot drums.