ok, so the EI (electrical interference) is coming from your instruments. Frustrating!No, it doesn't.
Do you rent a basement suite or live in any situation where someone else might have plugged something into the electrical system that you don't have control of? Flourescent lights can do that, but there are plenty of other things that can, also.
Is your audio interface USB connected? Sometimes USB can have issues with computer electrical noise, although it's much more rare with laptops since they don't contain 110v ac power supplies in the case....