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Weird Question.

I bet some make SOME difference... You get Hi Fi speaker, take the front off and they are so much more clear!
The frame that the grill is attached to affects the sound more than the grille itself, and then primarily in the higher frequencies well above those of electric bass.
 
Most studio monitors don't have a grill on the front, but that's a bit different to a bass amp I suppose.

I took the speaker grilles off my home stereo, and I think it sounds better, but it may be the placebo effect. :)

Anyhow, I'd much prefer to have well protected speakers, than a barely-noticable difference in sound quality. ;)