Generally, people who are happy with the stuff they have think it was worth it. So, the same answer applies here that works with most of the threads here: It Depends.
To address one common misconception: There has actually been more than 1 tube amp produced in the history of amplification. They are no more the same than every solid state amp, bass, or human are the same.
The amps I like the best are good amps. I had an Eden 15 years ago. I liked it. Had tube amps since then. Like them. Have a Genz Benz. Like it. My favorite clean tone is from a 435 watt Fender tube amp. I've gotten great distorted tone from 70's solid state Acoustic and Peavey amps. I've also played tube,hybrid, and solid state amps I didn't like.
The biggest difference is weight, a 300 LB tube amp won't be fun to move solo if you live on the 3rd floor and gig frequently. Not so bad if you are in a band and on good enough terms that you can help each other move gear. If you have PA support, such a big amp might not be needed, and you could get by with a 30 watt with an out to the board or a mic in front of it.
I've also tried some modellers, disposable Line 6 hardware and some pricey software. The software was fun to mess with when it was working, but ultimately the experience just left me realizing that computers are best used for porn or games. Anything else is just taking valuable drive space from one of those noble pursuits.