I play in a progressive alternative/metal band and like a sound that is ideal for real heavy music.
I currently use a Mesa Bass 400 into a Mesa Powerhouse 4x10 and an Avatar 2x10 pro. I was using a Goliath III in the place of the Avatar for a while, but wanted more lows/low mids bump. This setup is a little bit warm sounding for metal (but sounds great). Aggressive playing produces more aggressive almost s/s sounding tones. I boost mids, keep the treble a dash lower, run the bass around half or a dash less, frown EQ (mind you, this amp has kind of crazy settings... I wouldnt use this on any other amp)-- and cut through like crazy. For a more scooped and bottom heavy sound, I turn on my Sansamp BDDI.
To be honest, I think almost any head with a lot of power going into good rock/metal cabinets (for example, not SWR Goliath) with a Sansamp (or similar, like Hartke VXL) will get the job done beautifully.