Close. When you have two (or more) sources reproducing the same frequencies there are two (or more) paths to your ears, one from each source. As long as those paths are acoustically close to each other in distance there is no problem. But if the difference between the paths is 1/2 wavelength the sources are 180 out of phase and they cancel each other out. If they are a full wavelength apart they fully augment each other. At every other point they will either cancel or augment each other to some degree. Now a 100 Hz half-wavelength is 5.6 feet, so cancellation there is seldom a problem. But a 1kHz a half-wavelength is about 7 inches, so cancellation can easily occur there, as it can at any frequency that is short compared to the distance between the different sources.
If drivers (or cabinets) are vertically aligned then whatever difference there is in the acoustic pathways will remain a constant as one moves from side to side in front of the source. No matter where you stand it will sound the same. But if the drivers (or clustered cabinets) are placed horizontally then the pathway differentials will shift as you travel from side to side in front of the source, and it will sound different in every location. This is called 'comb filtering', as the response curve looks like the teeth of a comb, with different frequencies having various amounts of augmentation or degradation depending on the pathway induced phase differentials present at the listening position.
Drivers (or multiple cabinets) should never be placed horizontally, but unfortunately neither Leo Fender nor Jim Marshall, who set the standards for electric instrument speaker cabinetry, had any training in acoustic theory. They put drivers side by side because they didn't know any better, and the mold that they created is still in use, despite the fact that it's been known in the audio engineering community since at least 1930 that it's incorrect to do so.