I would think a DGCFA# would be more useful than a EADGC tuning.
I have a bass tuned that way, its no more useful than EADGC, unless you're playing a whole pile in D. Which I'm not.
I did think that DGCFBb(A#) with a drop tuner for CGCFBb would be very cool, almost covering the range of a 6er.