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A world without mind altering substances ?

Technically, anything that crosses the blood-brain barrier is a "mind altering substance", so being nit-picky about the question, the answer is we'd all be dead.

Skipping the semantics for a legit answer, the biggest change would be in the field of medicine. Anti-Depressants (MAOIs & SSRIs), lithium for bi-polar disorder, anesthetics for surgery, even headache medications (acetylsalicylic acid, acetaminophen & ibuprofen) among many others would all be eliminated. Obviously this would have a very negative effect for a significant portion of the population.

If the question were limited to "recreational" drugs, I can't really see that it would have a large change for humanity. Some lives (people who drink in moderation for instance) would be less rich, while others (long time drug abusers) would likely be better, though even that's debatable. Removing drugs as a coping mechanism doesn't ensure that alternative coping mechanisms would have developed in their place, but of course there's no way to tell.

The biggest change to our society if these substances didn't exist would likely be seen in the development of different cultures' religious & spiritual beliefs. OT is not the place to elaborate on this topic, but it's something I have given a lot of thought to in the past.
 
My thinking is that people that use mind altering substances to deal with stress , depression etc would develop other coping skills if they couldent self medicate. For those that use it to celebrate or party they just might take to other activites like having more sex or playing bass to enjoy themselves.

Do you know that brain chemistry it's not equal to everybody, and there is people that just can't deal with problems the same way the rest does?

I know what you're trying to get at, I would also like to see a more healthy drug-free world... But it's very hard to paint opinions like that one.

On the other hand, for those who think that just taking away ilegal drugs will solve the problem of the drug abuse, let me tell you, people who like drugs will buy it no matter how, people will sell it no matter how (there's to much money involved, I mean, one of the biggest bussines of the human history), and really, it's much cheaper and eassier to educate people to not use them.
 
so are we really talking about illegal drugs? or are we talking about mind-altering substances like sunlight, estrogen, testosterone, pheromones, caffeine, sugar, water, adrenaline, codeine, endorphins...

either way, it would suk. yes, suk. plus, think of the many self-righteous moralizing people who would be out of a job! what about them?